Overview - All That Is Bitter Is Sweet

Foshan's famous physician Du Yange has only one daughter, Linda Chung. Although she is intelligent and has a strong interest in Chinese medicine, Du Yange does not really see her as his successor because she is female. On the day of Linda's marriage to the mayor's son (Raymond Wong), a serious epidemic breaks out. Many patients, including Raymond, die after taking Du Yange's medicine, prompting the mayor (Pat Poon) to shut down the pharmacy. Experiencing such an abrupt change in her life, Linda is left feeling hopeless. At this time, Ruco Chan, a merchant suffering from a terminal illness, purchases the pharmacy's assets with the intention of reselling it for profit. To keep the pharmacy intact, Linda offers to treat his illness in exchange of him to not sell any of the assets. Through Ruco's connections, Linda meets a retired imperial physician (Choi Kwok Hing), who passes on his medical knowledge to her.  

Meanwhile, Raymond's twin brother (also played by Raymond) has returned home. Natalie Tong, the daughter of a military general, confesses her love for him, but he holds a crush on his former sister-in-law Linda instead. However, Linda and Ruco have already developed feelings for each other after overcoming many challenges together. Just as the pharmacy is reopened and everything seems to have settled down, Ruco's life begins counting down...